بررسی سطح سرمی‌لیپوپروتئین a (LPa) در بیماران جوان مبتلا به انفارکتوس میوکارد

Background and Objective: Coronary artery disease (CAD) in young people shows a different clinical, angiographic and pathophysiologic behavior in comparison to older age patients. Lipoprotein a (LPa) as a risk factor has a role for CAD so its serum measurement can be valuable for detecting people dispose to this group of diseases. Materials and Methods: We did a cross-secotinal study on a 120 people in 4 equal groups (patients with myocardial infarction and normal population, more and less than 45 years old). The data collected according to clinical examination and results of serum LPa, LDL, HDL levels. Then, data analyzed using to descriptive and analytical statistical tests i.e. the t test. Results: LPa level in both groups of normal people was 28.53±3.39 and both group of patients was 47.88±5.12 mg/dl (p= 0.015). Average LPa level between both groups of women less than 45 age old, in control 44.40±4.66 and patients group 81.03±12.14 was significant (p= 0.004). This value was significant between both group of women more than 45 years old in control 24.95±3.07 and patients groups 34.73±2.84 too (p= 0.001). Average LPa level between men less than 45 years in control 17.38±1.94 and patients groups 31.11±2.73 (p= 0.010) and men more than 45 years, in control 27.2±3.91 and patients groups 53.62±6.01 (p= 0.007) that was significant. Conclusion: Our study showed remarkable LPa level in coronary artery disease patients. Key words: Coronary artery disease risk factors, Lipoprotein a, Premature myocardial infarction Funding: This research was funded by Rafsanjan University of Medical Science. Conflict of interest: None declared. Ethical approval: The Ethics Committee of Rafsanjan University of Medical Science, approved the study. How to cite this article: Mirzaei M, Rahnama A, Esmaeelian F, Bakhsh H. Serum Level of Lipoprotein a (LPa) in Patients with Premature Myocardial Infarction. J Rafsanjan Univ Med Sci 2013 12(8): 655-66. [Farsi]